Investigating the essential roles of Ubiquitin-like molecules and the Ubiquitin Proteasome System

Ugo Mayor

Education

  • 2003: PhD in Biology at the University of Cambridge, UK.
  • 1998: MSc in Biochemistry at the University of Lund, Sweden.
  • 1998: BSc in Chemistry at the University of the Basque Country, Spain.

Research Appointments

  • 2009 - present: Ikerbasque Research Professor. Group Leader at CIC bioGUNE, Bilbao, Spain.
  • 2008 - 2009: Senior Research Associate, Genetics Dept, University of Cambridge, UK.
  • 2004 - 2008: Post-Doctoral Research Associate, WT CR UK Gurdon Institute, Cambridge, UK.
  • 2003: Research Associate, MRC Centre for Protein Engineering, Cambridge, UK.
Ugo Mayor

Research Interests

We are trying to elucidate the role of ubiquitination in neuronal development. Using a biochemical approach, we have developed a novel proteomic strategy that allows isolation of ubiquitinated material from the brain of a living organism. So far, we are using Drosophila for this purpose. We have also applied the same approach to isolate SUMO conjugates in a tissue specific manner.

Selected Publications

M. Franco, N. T. Seyfried, A. H. Brand, J. Peng and Ugo Mayor. A novel strategy to isolate ubiquitin conjugates reveals wide role of ubiquitination during neural development. Molecular & Cellular Proteomics (2011), 10(5):M110.002188 (Epub on 22nd September 2010) PMID: 20861518

U. Mayor and J. Peng. Deciphering Tissue-specific Ubiquitylation by Mass Spectrometry. Methods in Molecular Biology (2012), 832: 65-80

Partner

CIC bioGUNE

Fellow

Lucia Pirone

Project

In vivo requirements of the UBL modifier SUMO on SALL proteins function during steroidogenesis: D. melanogaster as a model system.