Investigating the essential roles of Ubiquitin-like molecules and the Ubiquitin Proteasome System

Research Project 8.
The role of proteasomal Ub receptor Rpn13 in mouse development.

Objectives

We aim to characterize novel Ub- and UBL-binding domains, with special emphasis on linkage-specific UBDs (primarily K63-, K48- and linear Ub UBDs). We have generated several conditional knock-out mouse models for UBDs previously discovered in our group, including Rpn13 and want to study their role in disease and development. We would like to fully characterize conditional knock-out mouse model of Rpn13.