Investigating the essential roles of Ubiquitin-like molecules and the Ubiquitin Proteasome System

Research Project 7.
Mass spectrometry analysis of ubiquitylated and SUMOylated proteins.

Objectives

Applying mass spectrometry to the proteome-wide scale identification of individual target proteins that are (co) regulated by SUMOs and Ub during DDR. This knowledge will be used to identify new therapeutic targets that can be used to develop small molecule inhibitors of processes involved in diseases, such as cancer and neurodegeneration.

Collaborators

Alfred Vertegaal (LUMC)