Investigating the essential roles of Ubiquitin-like molecules and the Ubiquitin Proteasome System

Katarzyna Kliza

Education

  • 2006-2011
    Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology (Cracow, PL) MSc studies in Biotechnology
    Dissertation: MCPIP1 influence on the activation of NFκB and MAP kinase signal transduction pathways in HepG2 cells stimulated with interleukin 1β (27.06.2011).

Professional Experience

  • 03.2012 - present
    Goethe University School of Medicine
    Institute of Biochemistry II
     (Frankfurt am Main, Germany)
    PhD Student:
    • The role of proteasomalUb receptor Rpn13 in mouse development.
  • 09.2011-02.2012
    Goethe University School of Medicine
    Institute of Biochemistry II 
    (Frankfurt am Main, Germany)
    Intern:
    • Supervisor: PhD Koraljka Husnjak. Funded by LOEWE CGT.
    • Ubiquitin signals in Regulation of Protein Stability.
  • 10.2010-03.2011
    University Medical Center Groningen
    Radiation & Stress Cell Biology Department (Groningen, The Nederlands)
    Erasmus exchange student:
    • Supervisor: Prof. Harm H. Kampinga.
    • Investigation of the role of DNAJB chaperone family members (DNAJB6 and DNAJB7) in protein quality control.
  • 07-09.2010
    Ludwig-Maximilians-Universität
    Christian Haass's Laboratory for Neurodegenerative Disease Research (Munich, Germany)
    Intern:
    • Supervisor: PhD Michael Willem. Funded by Amgen Scholars Programme.
    • Identification of the cleavage site in a new substrate of the enzyme BACE1.
  • 02.2008-07.2011
    Jagiellonian University
    Cell Biochemistry Department, Factulty of Biochemistry, Biophysics and Biotechnology (Cracow, Poland)
    MSc student:
    • Supervisor: Associate Professor, PhD Jolanta Jura.
    1. Screening of clones after yeast-two hybrid system experiment.
    2. Detections of mutations in PARK 2 gene of patients with early-onset parkinsonism.
    3. Work on the influence of MCPIP on mRNA half-life time in cancer tissue.
    4. MCPIP1 influence on the activation of NFκB and MAP kinase signal transduction pathways in HepG2 cells stimulated with interleukin 1β.

Conferences

1. Poster presentation at the NEURONUS Student Neuroscience Conference, Cracow (Poland), April 25-27, 2010.

"Heteroduplex analysis in PARK2 gene in patients with autosomal recessive early-onset Parkinsonism".

2. Poster presentation at the International Interdisciplinary Student and Young Researcher Conference, Czestochowa (Poland), May, 6-7, 2010.

"Anti-cancer vaccines based on heat shock proteins'', ,,VSELs - hope for health and longevity?"

3. Participation in the conference "NEXT GENERATION SEQUENCING 2010", Warsaw (Poland), June 21, 2010.

4. Poster presentation at the Amgen Scholars Summer Symposium, Cambridge (UK), September 6-8, 2010.

"Identification of the cleavage site in a new BACE1 substrate"

5. Poster presentation at the VI International Scientific Conference for Students and PhD Students ,,Youth and Progress of Biology'', Faculty of Biology, Ivan Franko National University, Lviv (Ukraine), September 21–24, 2010.

"Ubiquitin binding domains of MCPIP and NF-kappaB activity"

The poster was also presented at EMBO conference ,,At the joint edge of cellular microbiology and cell biology'', Cracow (Poland), October, 9-14, 2010.

6. Poster presentation at the Dutch Chaperone Meeting, UMCG, Groningen (Netherlands), January

28, 2011.

"Elucidating the role of DNAJB7 in protein quality control"

Workshop

1. 6th Stem Cell Summer School organized by Department of Transplantation, Jagiellonian

University Medical College, Cracow, Poland, June 5-6, 2009.

2. "Scientific Writing and Publishing" organized by Amgen Scholars Program and Pete Moore Comunications, AschauimChiemgau, Germany, July 25, 2010.

3. "Poster design and presentation" organized by Amgen Scholars Program and Pete Moore Comunications, Munich, Germany, August 20, 2010.

Scholarship and prizes

1. Scholarship for learning achievements from Jagiellonian University, academic year: 2009-2010.

2. Socrates Erasmus Scholarship, November 2010- March 2011.

3. Scholarship from Amgen Scholars Foundation, July 2010- September 2011.

4. Scholarship for outstanding achievements from SapereAuso Foundation, academic year: 2010-2011.

5. Scholarship for outstanding achievements from Polish Minister of National Education, academic year: 2010-2011

6. Scholarship from LOEWE CGT, September 2011- February 2012.

7. 1st Poster Prize at the VI International Scientific Conference for Students and PhD Students "Youth and Progress of Biology", Faculty of Biology, Ivan Franko National University, Lviv, Ukraine, September 21–24, 2010.

Articles

KatarzynaKliza, e-Biotechnologia (ISSN 2080-8682), 2010, article in polish, "The role of microRNA in oncogenesis".

 KatarzynaKlizaBioInfoArticles 2008, article in Polish, available on-line on Department of Computational Biophysics and Bioinformatics Faculty of Biochemistry, Biophysics and Biotechnology of Jagiellonian University. bioinfo.mol.uj.edu.pl/articles/Kliza08

Partner

Biochem2

Group

Koraljka Husnjak

Project

The role of proteasomal Ub receptor Rpn13 in mouse development.