Investigating the essential roles of Ubiquitin-like molecules and the Ubiquitin Proteasome System

Farid El Oualid

Education

  • 2005: PhD in Organic Chemistry at Leiden University, Leiden, The Netherlands.
  • 2000: MSc in Chemistry at Leiden University, Leiden, The Netherlands.

Research Appointments

  • Oct 2010 - present: Co-founder and Chief Operations Officer UbiQ, Amsterdam, The Netherlands
  • Aug 2008 - present: Postdoctoral Researcher, Division of Cell Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • March 2008: Postdoctoral Researcher (short-term appointment), Department of Clinical Medicine, Oxford University, Oxford, United Kingdom.
  • Aug 2005: Marie Curie Postdoctoral Fellow, Department of Chemistry, Oxford University, Oxford, UK.
  • >1999-2000: Research scientist at GlaxoSmithKline Medicines Research Centre, Stevenage, United Kingdom.
Farid El Oualid

Research Interests

UbiQ is a spin-out of the Netherlands Cancer Institute in Amsterdam, founded in October 2010 by Huib Ovaa (CSO), Farid El Oualid (COO) and Alfred Nijkerk (CEO). UbiQ focuses on the development and commercialisation of research tools that will enable drug discovery in the rapidly expanding ubiquitin-proteasome field.

Selected Publications

El Oualid F, Merkx R, Ekkebus R, Hameed DS, Smit JJ, de Jong A, Hilkmann H, Sixma TK, Ovaa H. Chemical Synthesis of Ubiquitin, Ubiquitin-based Probes and Diubiquitin. Angew. Chemie Int. Ed. 2010, 49, 10149 − 10153. DOI: 10.1002/ anie.201005995

Shanmugham A, Fish A, Luna-Vargas MPA, Faesen AC, El Oualid F, Sixma TK, Ovaa H. Non-hydrolyzalbe ubiquitin isopeptide isosteres as deubiquinating enzyme probes. J. Am. Chem. Soc. 2010, 132, 8834 − 8835. DOI: 10.1021/ja101803s

El Oualid F, Cohen LH, van der Marel GA, Overhand, M. Inhibitors of protein: Geranylgeranyl transferases. Curr. Med. Chem. 2006, 13, 2385 − 2427. DOI: 10.2174/092986706777935078

El Oualid F, van den Elst H, Leroy IM, Pieterman E, Cohen LH, Burm BEA, Overkleeft HS, van der Marel GA, Overhand, M. A combinatorial approach toward the generation of ambiphilic peptide-based inhibitors of protein : geranylgeranyl transferase-1. J. Comb. Chem. 2005, 7, 703 − 713. DOI: 10.1021/cc0500203

Awards and Achievements

  • 2011 Valorisation grant Fase-2 Technology Foundation STW.
  • 2010 Valorisation grant Fase-1 Technology Foundation STW.
  • 2009 Valorisation voucher (Netherlands Proteomics Centre).
  • 2009 Pre-Seed grant (Netherlands Genomics Initiative).
  • 2008 Marie-Curie European Reintegration Grant (European Commission).
  • 2005 Marie-Curie Fellowship (European Commission)
  • 2005 TALENT-fellowship (Netherlands Foundation for Scientific Research)
  • 1999 Research contract GlaxoSmithKline

Partner

UbiQ