Investigating the essential roles of Ubiquitin-like molecules and the Ubiquitin Proteasome System
Education
Research Appointments
Research Interests
UbiQ is a spin-out of the Netherlands Cancer Institute in Amsterdam, founded in October 2010 by Huib Ovaa (CSO), Farid El Oualid (COO) and Alfred Nijkerk (CEO). UbiQ focuses on the development and commercialisation of research tools that will enable drug discovery in the rapidly expanding ubiquitin-proteasome field.
Selected Publications
El Oualid F, Merkx R, Ekkebus R, Hameed DS, Smit JJ, de Jong A, Hilkmann H, Sixma TK, Ovaa H. Chemical Synthesis of Ubiquitin, Ubiquitin-based Probes and Diubiquitin. Angew. Chemie Int. Ed. 2010, 49, 10149 − 10153. DOI: 10.1002/ anie.201005995
Shanmugham A, Fish A, Luna-Vargas MPA, Faesen AC, El Oualid F, Sixma TK, Ovaa H. Non-hydrolyzalbe ubiquitin isopeptide isosteres as deubiquinating enzyme probes. J. Am. Chem. Soc. 2010, 132, 8834 − 8835. DOI: 10.1021/ja101803s
El Oualid F, Cohen LH, van der Marel GA, Overhand, M. Inhibitors of protein: Geranylgeranyl transferases. Curr. Med. Chem. 2006, 13, 2385 − 2427. DOI: 10.2174/092986706777935078
El Oualid F, van den Elst H, Leroy IM, Pieterman E, Cohen LH, Burm BEA, Overkleeft HS, van der Marel GA, Overhand, M. A combinatorial approach toward the generation of ambiphilic peptide-based inhibitors of protein : geranylgeranyl transferase-1. J. Comb. Chem. 2005, 7, 703 − 713. DOI: 10.1021/cc0500203
Awards and Achievements