Investigating the essential roles of Ubiquitin-like molecules and the Ubiquitin Proteasome System

Aysegul Sapmaz

Education

  • October 2012-present
Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology MSc studies in Biotechnology Dissertation: Influence of Peptidyl Arginine Deiminases on the biological properties
/30th June/ of human cathelicidin (LL-37)

Postdoctoral Fellow. Division of Cell Biology II (Ovaa’s group). Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital (NKI-AVL).

2006-2012
Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology MSc studies in Biotechnology Dissertation: Influence of Peptidyl Arginine Deiminases on the biological properties
/30th June/ of human cathelicidin (LL-37)

PhD. Department of Biological Sciences. Middle East Technical University, Ankara, Turkey. 

2003-2006

Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology MSc studies in Biotechnology Dissertation: Influence of Peptidyl Arginine Deiminases on the biological properties
/30th June/ of human cathelicidin (LL-37)

MSc with honors. Biotechnology Institute. Ankara University, Ankara, Turkey.

Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology MSc studies in Biotechnology Dissertation: Influence of Peptidyl Arginine Deiminases on the biological properties

/30th June/ of human cathelicidin (LL-37)Postdoctoral Fellow. Division of Cell Biology II (Ovaa’s group). Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital (NKI-AVL)

• October 2012-present

Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology MSc studies in Biotechnology Dissertation: Influence of Peptidyl Arginine Deiminases on the biological properties
/30th June/ of human cathelicidin (LL-37)

Postdoctoral Fellow. Division of Cell Biology II (Ovaa’s group). Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital (NKI-AVL)

Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology MSc studies in Biotechnology Dissertation: Influence of Peptidyl Arginine Deiminases on the biological properties

/30th June/ of human cathelicidin (LL-37)Postdoctoral Fellow. Division of Cell Biology II (Ovaa’s group). Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital (NKI-AVL)

• October 2012-present

Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology MSc studies in Biotechnology Dissertation: Influence of Peptidyl Arginine Deiminases on the biological properties
/30th June/ of human cathelicidin (LL-37)

Postdoctoral Fellow. Division of Cell Biology II (Ovaa’s group). Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital (NKI-AVL)

• 1998-2002

Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology MSc studies in Biotechnology Dissertation: Influence of Peptidyl Arginine Deiminases on the biological properties
/30th June/ of human cathelicidin (LL-37)

BSc with honors. Department of Biology. Ankara University, Ankara, Turkey.

Professional Experience

 

 • October 2012-present
Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology MSc studies in Biotechnology Dissertation: Influence of Peptidyl Arginine Deiminases on the biological properties
/30th June/ of human cathelicidin (LL-37)

Postdoctoral Fellow. Division of Cell Biology II (Ovaa’s group). Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital (NKI-AVL).

 May 2011-May 2012

Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology MSc studies in Biotechnology Dissertation: Influence of Peptidyl Arginine Deiminases on the biological properties
/30th June/ of human cathelicidin (LL-37)

Visiting PhD student. Division of Cell Biology II (Ovaa’s group) Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital (NKI-AVL).

Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology MSc studies in Biotechnology Dissertation: Influence of Peptidyl Arginine Deiminases on the biological properties

/30th June/ of human cathelicidin (LL-37)Postdoctoral Fellow. Division of Cell Biology II (Ovaa’s group). Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital (NKI-AVL)

• October 2012-present

Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology MSc studies in Biotechnology Dissertation: Influence of Peptidyl Arginine Deiminases on the biological properties
/30th June/ of human cathelicidin (LL-37)

Postdoctoral Fellow. Division of Cell Biology II (Ovaa’s group). Netherlands Cancer Institute-Antoni van Leeuwenhoek hospital (NKI-AVL)

• 2005-2012

Jagiellonian University Faculty of Biochemistry, Biophysics and Biotechnology MSc studies in Biotechnology Dissertation: Influence of Peptidyl Arginine Deiminases on the biological properties
/30th June/ of human cathelicidin (LL-37)

Research Assistant and PhD student. Department of Biological Sciences. Middle East Technical University, Ankara, Turkey.

2005-2012

Teaching Assistant. Department of Biological Sciences. Middle East Technical University, Ankara, Turkey.

• GENE475-Molecular Biology Laboratory

• GENE367- General and Molecular Genetics Laboratory

• GENE104- Molecular and Cellular Biology II (Laboratory)

Conferences

 

2010 
Akman Tuncer HB, Sapmaz A, Akhavantabasi S, Erson AE. Characterization of a ubiquitin specific protease in the 17q23 amplicon. The European Association for Cancer Research 21st meeting, Oslo, Norway, June 26-29 2010.

2009
Sapmaz A., Akhavantabasi S., Korkmaz M., Erson A.E., Investigation of the effect of different boron concentration on breast cancer cell proliferation. XI. National Medical Biology and Genetics Congress, 28-31 October 2009. Nevsehir, Turkey.

2009
Sapmaz A, Erson AE. Functional Characterization of an Oncogene Candidate, USP32, in Breast Cancer. Int. Symposium on Biotechnology, Ankara, Turkey, Sept. 27-30, 2009.

2009
Sapmaz A, Akhavantabasi S, Petty EM, Erson AE. Characterization of an Oncogene Candidate, USP32, on 17q23, European Human Genetics Conference, Austria Center Vienna, May 23 - 26, 2009.

2008
Sapmaz A, Yuce R, Erson AE, Identification of the function and regulation mechanism of USP32, EMBO YOUNG SCIENTISTS FORUM, Istanbul, Turkey, Feb 20-22, 2008.

2006
Sapmaz A., Özen Karatayli S.C., Dagli U., Kiliç Z.M., Törüner M., Çelik Y., Özkan M., Soykan I., Çetinkaya H., Ülker A., Özden A., and Bozdayı A.M.. Correlation between Multidrug Resistance 1 (Mdr1) Single Nucleotide Polymorphisms and Inflammatory Bowel Disease. 23th National Gastroenterology Congress, 4-7 November 2006, Istanbul.

 

Workshop

2011
1st EACR-OECI Joint Training Course "Molecular PATHOLOGY approach to cancer" Amsterdam 7th - 9th March 2011.

2012
UPStream Workshop on Ubiquitin and SUMO in Frankfurt 3th-7th December 2012.

Scholarship and prizes


2005
 Full PhD scholarship from Higher Education Council (2005-present).

2006-2010
The Scientific and Technological Research Council of Turkey (TUBITAK)- National Scholarship Programme for PhD Students (2006-2010) (a scholarship programme for students pursuing a PhD in a university in Turkey (about 700-800 PhD students supported per year).

2010
Publication Award from Middle East Technical University for Mammalian Genome. 2010 Aug; 21(7-8): 388-397.

2010
Publication Award from TUBITAK for Mammalian Genome. 2010 Aug; 21(7-8): 388-397.

2009
Travel Grant for European Human Genetics Conference, Austria Centre Vienna, May 23 - 26, 2009.

2006
Awards for second prize (23th National Gastroenterology Congress, 4-7 November 2006, Istanbul, Turkey).

2003-2004
Highest cumulative graduate student award (2003-2004) Biotechnology Institute, Ankara University.

Publications

2011
Akhavantabasi S, Sapmaz A, Tuna S, Erson-Bensan AE. miR-125b targets ARID3B in breast cancer cells. Cell Struct Funct. 2012;37(1):27-38.

2010
Akhavantabasi S*, Akman HB*, Sapmaz A*, Keller J, Petty EM, Erson AE. USP32 is an active, membrane bound ubiquitin protease overexpressed in breast cancers. Mamm Genome. 2010 Aug; 21(7-8): 388-397. *Equal Contribution.

2008
Sapmaz A., Ozen Karatayli S.C., Dagli U., Kiliç Z.M., Toruner M., Celik Y., Ozkan M., Soykan I., Cetinkaya H., Ulker A., Ozden A., and Bozdayi A.M. Effects of polymorphism in G2677T/A triallelic region of MDR1 gene in Turkish patients with inflammatory bowel disease. Turk J Gastroenterol. 2008 September; 19(3):168-73.

Partner

NKI-AVL

Group

Huib Ovaa